I would try to do what Charlton used to do. I'd pretty much ignore comics fandom, the way Archie Comics tends to do today. I'd try to focus on getting casual readers, particularly kids and people who don't want to follow lots of continued stories.

I wouldn't try to compete with DC and Marvel with their style of superhero/fantasy comics, because they already do that better than anyone else. (That would be like trying to compete against Archie's teen humor comics. Archie would win.)

I'd try to make my comics really cheap. There are lots of "dollar stores" around these days which sell all sorts of things for only a dollar. Some of them even have DVDs for a dollar each! I would try to put out some "Dollar Comics" to sell in such dollar stores. To keep costs down, perhaps the material within would be reprints of old 1950s public domain comics or foreign comics or taken from comic strips. I'd try to get the rights to put out comicbook versions of popular comic strips. In Australia, Frew has published a lot of vintage as well as brand-new Phantom comics; I'd try to reprint them for American audiences. There could even be an American version of the Beano (long-running U.K. series). A lot of the material would be considered "new" because it hasn't been seen before by most people in the U.S.

There could also be some new material, new comics made. I would focus on anthology titles with short stories by some of the old-timers as well as people just starting out who may have that traditional style. I'd let the creators own their own characters, have their own copyright, and would discourage a Marvel/DC-style assembly-line method of production where tasks are divided among different people. If it's an 8-page story, the artist might be able to pencil, ink, and letter it all himself, and might even prefer to do so, especially since he will own the artwork.

I'd start out small, just putting out some stuff in dollar stores and so on, beneath the radar of fandom until things got more successful.